IDA - Intelligent Data Analysis Research Group

BibTeX Entry

@article{jpi_journal,
  category = {ida-publications},
  author = {Karel Stryczek and Petr Horacek and Jiri Klema and Xavier Castells and Bob Stewart and Jean-Marie Geoffroy},
  title = {Capitalizing on Aggregate Data for Gaining Process Understanding––Effect of Raw Material, Environmental and Process Conditions on the Dissolution Rate of a Sustained Release Product},
  journal = {Journal of Pharmaceutical Innovation},
  volume = {2},
  number = {1-2},
  year = {2007},
  language = {english},
  publisher = {Springer New York},
  issn = {1872-5120},
  pages = {6-17},
  month = {October},
  url = {http://springerlink.com/content/104843g212171n84/fulltext.pdf},
  keywords = {Time-series data, critical process parameters},
  abstract = {Continuous improvement of pharmaceutical manufacturing operations has not evolved at the same rate as it has in other industries. Although time-series data are routinely collected as part of equipment control systems, the data are usually not thoroughly evaluated. This article investigates batch data, in-process and release laboratory test data and time-series data from granulation, fluid-bed drying and coating operations in an effort to determine which parameters are most critical to the dissolution of a matrix release, solid oral dosage form of a poorly soluble drug.},
  vvvs = {1},
  projnum = {10/87062/13133},
  projects = {ML/REL},
}


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